What if there was an acellular biomaterial that supported tissue repair with a scaffold-like matrix having an all natural structure and composition?

A unique biomaterial that does not encapsulate when surgically implanted, but is gradually remodeled, leaving behind organized tissue.

Sounds like futuristic technology - but it’s available today.

SyntheMed Inc. is a biomaterials company dedicated to developing and marketing proprietary polymer products used to prevent or reduce adhesions that may form in a a broad range of surgical procedures.

Cormatrix ECM consists of a complex of collagen: types I (predominant),III, IV, V, VI 92% of dry weight

• Glycosaminoglycans (GAGs): chondroitin sulfate A and B, heparan, heparin, hyaluronic acid
• Glycoproteins: fibronectin, entactin, laminin
• Proteoglycans: decorin, perlecan
• Growth factors: TGFb, FGF-2, VEGF, PDGF, HDGF

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"Post-operative adhesion formation is a significant clinical complication that surgeons routinely encounter in secondary cardiac surgical procedures. I have been pleased with the handling characteristics of REPEL-CV and am impressed by the results of this randomized study. I believe that REPEL-CV may offer a significant advance in the treatment of patients undergoing cardiac surgery."

Carl Backer, MD

A.C. Buehler Professor of Surgery

Children's Memorial Hospital

Feinberg School of Medicine

Northwestern University

Cardica, Inc. designs and manufactures proprietary products which automate the connections, or anastomoses, of blood vessels during coronary artery bypass graft (CABG) and other grafting surgeries.

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The PAS-Port system is a fully automated device used to perform an anastomosis between a saphenous vein and the aorta during either on- or off-pump CABG surgery

The PAS-Port system is designed to:

• Allow the surgeon to load the bypass graft and rapidly complete the anastomosis, typically in approximately one minute;
• Eliminate aortic clamping and manipulation. Eliminating clamping may greatly reduce the risk of particle release and ensuing neurocognitive events;
• Provide one-turn aortotomy and anastomosis;
• Reduces the time required for anastomosis; 
• Produces consistent, reproducible anastomoses, largely independent of surgical technique and skill set;
• Ensures a secure graft attachment allowing for variable take-off angles;
• Leaves no metal within the graft lumen;
• it can be loaded into the system without damaging endothelial cells while maximizing the orifice, which is especially important in small grafts; and
• Allows mechanically governed repeatability and reduced complications.